Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d,l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis.

Abstract

HNV-loaded PLGA microspheres (HNV-PLGA MSs) were prepared by water-in-oil-in-water (w/o/w) double emulsion solvent evaporation technique. The surface of prepared HNV-PLGA MSs is smooth and nonporous with an average diameter of 69.9 μm. The drug-loading rate and encapsulation rate of HNV-PLGA MSs are 4.40 ± 0.26% and 48.51 ± 14.83%, respectively. Additionally, 43.36% of HNV was released from PLGA MSs after seven days of incubation. The antibacterial effects of HNV released from PLGA were as good as the pure HNV. HNV-loaded PLGA microspheres were successfully prepared using double emulsion solvent evaporation technique and their properties met the requirements for local anti-infection.

• Authors: Haibo Yang, Yujie Hao, Qiming Liu, Zhanhu Mi, Zhibin Wang, Lei Zhu, Qingling Feng, Ningmin Hu
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 45 Issue 7 Pg. 1326-1330 (Nov 2017) ISSN: 2169-141X [Electronic] England
• PMID: 27776425 (Publication Type: Journal Article)

Chemical References

• Capsules
• Drug Carriers
• Oils
• Water
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• Vancomycin
• norvancomycin

Topics

• Capsules
• Drug Carriers (chemistry)
• Drug Liberation
• Lactic Acid (chemistry)
• Microspheres
• Oils (chemistry)
• Osteomyelitis (drug therapy)
• Particle Size
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Vancomycin (analogs & derivatives, chemistry, therapeutic use)
• Water (chemistry)