Purification of dolabellanin-C an antineoplastic glycoprotein in the body fluid of a sea hare, Dolabella auricularia.

Abstract

An antineoplastic factor, dolabellanin C, inducing tumor lysis was purified to apparent homogeneity from the body fluid of the sea hare Dollabella auricularia. Purified dolabellanin C is a glyco-protein of 215 K daltons containing 3 subunits of 70 K daltons. The amino acid sequence of the amino terminal region was also determined. This factor was active even at 0.38 ng protein/ml, but did not lyse normal white or red blood cells.

• Authors: J Kisugi, H Kamiya, M Yamazaki
• Journal: Developmental and comparative immunology (Dev Comp Immunol) Vol. 13 Issue 1 Pg. 3-8 ( 1989) ISSN: 0145-305X [Print] United States
• PMID: 2767307 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Glycoproteins
• dolabellanin C protein, Dollabella auricularia

Topics

• Amino Acid Sequence
• Animals
• Antineoplastic Agents (isolation & purification)
• Electrophoresis, Polyacrylamide Gel
• Glycoproteins (isolation & purification)
• Molecular Sequence Data
• Molecular Weight
• Mollusca