Abstract | BACKGROUND: New patterns in epidemiological characteristics of people living with HIV infection (PLWH) and the introduction of Highly Active Antiretroviral Therapy ( HAART) have changed the profile of hospital admissions in this population. The aim of this study was to evaluate trends in hospital admissions, re-admissions, and mortality rates in HIV patients and to analyze the role of HCV co-infection. METHODS: A retrospective cohort study conducted on all hospital admissions of HIV patients between 1993 and 2013. The study time was divided in two periods (1993-2002 and 2003-2013) to be compared by conducting a comparative cross-sectional analysis. RESULTS: A total of 22,901 patient-years were included in the analysis, with 6917 hospital admissions, corresponding to 1937 subjects (75% male, mean age 36±11 years, 37% HIV/HCV co-infected patients). The median length of hospital stay was 8 days (5-16), and the 30-day hospital re-admission rate was 20.1%. A significant decrease in hospital admissions related with infectious and psychiatric diseases was observed in the last period (2003-2013), but there was an increase in those related with malignancies, cardiovascular, gastrointestinal, and chronic respiratory diseases. In-hospital mortality remained high (6.8% in the first period vs. 6.3% in the second one), with a progressive increase of non- AIDS-defining illness deaths (37.9% vs. 68.3%, P<.001). The admission rate significantly dropped after 1996 (4.9% yearly), but it was less pronounced in HCV co-infected patients (1.7% yearly). CONCLUSIONS:
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Authors | Héctor Meijide, Álvaro Mena, Iria Rodríguez-Osorio, Sonia Pértega, Ángeles Castro-Iglesias, Guillermo Rodríguez-Martínez, José Pedreira, Eva Poveda |
Journal | Enfermedades infecciosas y microbiologia clinica
(Enferm Infecc Microbiol Clin)
Vol. 35
Issue 1
Pg. 20-26
(Jan 2017)
ISSN: 1578-1852 [Electronic] Spain |
PMID | 27609631
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved. |
Topics |
- Adult
- Cohort Studies
- Coinfection
(microbiology)
- Cross-Sectional Studies
- Female
- HIV Infections
(complications, mortality)
- Hepatitis C, Chronic
(complications, mortality)
- Hospital Mortality
(trends)
- Humans
- Male
- Patient Admission
(statistics & numerical data, trends)
- Retrospective Studies
- Time Factors
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