Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection.

Abstract

We discuss a 48-year old, who presented with upper epigastrium pain associated with early satiety and significant weight loss. Physical examination revealed a thickening and darkening of skins around the skin folds, scalp, back and front of abdomen. A diagnosis of gastro-esophageal junction adenocarcinoma was confirmed by oesophagogastroduodenoscopy (OGDS) and biopsy. The biopsy of the skin lesion revealed a diagnosis of acanthosis nigricans, He underwent a total gastrectomy followed by adjuvant chemo-radiotherapy. Recovery is unremarkable. Interestingly, the skin lesions disappear following our therapy. We believe this may be attributed to the treatment of the malignancy. We highlight the interesting association, pathophysiology and therapy.

• Authors: A V Jagwani, R Reynu, C A Affirul, M T Mustafa, N R Kosai
• Journal: La Clinica terapeutica (Clin Ter) 2016 Jul-Aug Vol. 167 Issue 4 Pg. 99-100 ISSN: 1972-6007 [Electronic] Italy
• PMID: 27598021 (Publication Type: Case Reports, Journal Article)

Topics

• Acanthosis Nigricans (complications)
• Adenocarcinoma (complications, surgery)
• Female
• Humans
• Male
• Middle Aged
• Stomach Neoplasms (complications, surgery)