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Nodal signaling modulates the expression of Oct-4 via nuclear translocation of β-catenin in lung and prostate cancer cells.

Abstract
Nodal is a member of transforming growth factor beta (TGF-β) superfamily. Nodal promotes the self-renewal of human cancer stem cells (CSCs) and triggers carcinogenesis of human cancers via an autocrine manner through Smad2/3 pathway. In our study, generation of Nodal-overexpressed cancer cells was constructed, and the effect of Nodal on the stem cell marker Oct-4 was evaluated by overexpression or blocked Nodal/ALKs signaling pathway in non-small cell lung cancer cells A549 and prostate cancer cells PC3. Functionally, Nodal also increased the proliferation via the β-catenin nuclear translocation. This increase was attributed to GSK-3β dephosphorylating, and activin receptor-like kinase 4/7 (ALK4/7) played a major role in human cancer cells. Our study provides a positive understanding of Nodal function in cancer cells and suggests a potential novel target for clinical therapeutic research.
AuthorsYi-Fei Qi, Long Wu, Zi-Qian Li, Meng-Ling Wu, Hai-Fang Wang, Ka-Ying Chan, Lin-Lin Lu, Shao-Hui Cai, Hong-Sheng Wang, Jun Du
JournalArchives of biochemistry and biophysics (Arch Biochem Biophys) Vol. 608 Pg. 34-41 (10 15 2016) ISSN: 1096-0384 [Electronic] United States
PMID27592306 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2016 Elsevier Inc. All rights reserved.
Chemical References
  • CTNNB1 protein, human
  • NODAL protein, human
  • Nodal Protein
  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • beta Catenin
  • ACVR1B protein, human
  • Activin Receptors, Type I
Topics
  • A549 Cells
  • Active Transport, Cell Nucleus
  • Activin Receptors, Type I (metabolism)
  • Cell Line, Tumor
  • Cell Nucleus (metabolism)
  • Cell Proliferation
  • Cytoplasm (metabolism)
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Nodal Protein (metabolism)
  • Octamer Transcription Factor-3 (metabolism)
  • Prostatic Neoplasms (metabolism)
  • Signal Transduction
  • Transfection
  • beta Catenin (metabolism)

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