Risk Factors for Local Recurrence or Metastasis of Eyelid Sebaceous Gland Carcinoma After Wide Excision With Paraffin Section Control.

Abstract

PURPOSE:

To identify risk factors for local recurrence and metastasis of sebaceous gland carcinoma (SGC) after wide excision with paraffin section control.

DESIGN:

Retrospective, observational case-control study.

METHODS:

Setting: Single institution.

PATIENT POPULATION:

Thirty-four patients with SGC who had undergone excision with 5-mm surgical margins and paraffin section pathologic analysis. Observational Procedures: The following were considered potential risk factors for local recurrence/metastasis of SGC: patient's sex, patient's age, initial diagnosis at other clinics, topical treatments at other clinics, interval between appearance of symptoms and referral to our institution, tumor location, tumor origin, tumor presentation pattern, T category, tumor size, presence/or absence of pagetoid spread, tumor differentiation, mitosis grade, growth pattern. Logistic regression analysis was performed to identify the actual risk factors.

MAIN OUTCOME MEASURES:

Risk factors for local recurrence or metastasis of SGC after wide excision with paraffin section control.

RESULTS:

Involvement of both upper and lower eyelids, topical treatments at other clinics, multicentric origin, diffuse pattern, stage T3a, large tumor size, and a nonlobular pattern significantly influenced local recurrence/metastasis (P < .050). Pagetoid spread tended to affect local recurrence/metastasis (P = .052). The other items did not significantly influence local recurrence/metastasis (P > .050).

CONCLUSIONS:

This study identified risk factors for local recurrence or metastasis of SGC after wide excision with paraffin section pathologic analysis. The results of this study will be helpful to surgeons when planning additional management, such as map biopsy or adjuvant treatment.

• Authors: Yasuhiro Takahashi, Emiko Takahashi, Shunsuke Nakakura, Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Hirohiko Kakizaki
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 171 Pg. 67-74 (Nov 2016) ISSN: 1879-1891 [Electronic] United States
• PMID: 27590119 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Adenocarcinoma, Sebaceous (diagnosis, secondary, surgery)
• Adult
• Aged
• Aged, 80 and over
• Eyelid Neoplasms (diagnosis, secondary, surgery)
• Female
• Follow-Up Studies
• Humans
• Incidence
• Japan (epidemiology)
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (epidemiology)
• Ophthalmologic Surgical Procedures (methods)
• Retrospective Studies
• Risk Assessment (methods)
• Risk Factors
• Sebaceous Gland Neoplasms (pathology, surgery)
• Survival Rate (trends)