[THE CORRECTION WITH NOOPHEN OF AUTONOMIC DYSFUNCTION IN YOUNG MEN WITH HYPERTENSION].

Abstract

The aim of this study was to investigate the influence of antihypertensive therapy with adding of gamma-amino-beta-phenylbutyric acid hydrochloride on the autonornic regulation of tcardiovascular system and the psychoemotional status in young men with hypertension. The study included 58 male with hypertension, aged 18-39 years (mean age 31.7 yearst 2.3 years), of them 28 patients (group I) administered beta-blocker and the other received a complex therapy which included beta-blocker and gamma-amino-beta-phenylbutyric acid hydrochiotide--Noofen ("OlainFarm", Latvia) 250 mg 3 times a day for 4 weeks. The control group consisted of 20 healthy indi&iduals aged 18-39 years (mean age 31.5 years +/- 2.5 years). The examination included of standard clinical; biochemical and instrumental investigatIons. We conducted a clinical measurement of blorid pressure, ambulatory blood pressure monitoring (ABPM), Doppler echocardiography, heart rate variability, autononlic symptoms questionnaire and Spielberger--Hanina Anxiety Scale. Analysis of circadian blbod pressure profile arid autonomic nervous system state in young men with hypertension, in spite of the short disenle history demonstratnl violations of the blood pressure circadian rhythm associated with the violation of the autonomic regulation of cardiovascular system as indreased sympathetic activity and decreased parasympathetic activity heart tate. In hypertensive patients with autonomic dysfunction we noted a reduction of level of mental health, which was reflected in an increase in'the number of people with high and moderate levels of reactive and personal anxiety It has been demonstratedthat the use of combination therapy with adding Noofen in young hypertensive men and autonomic dysfunction helped significantly improve the HRV parameters and restore autonomic balance on time parameters of heart rate variability reduced the level of reactive anxiety and imprdved the psychoemotional state.

• Authors: I I Knyazkova, N V Kuzminova, N Yu Osovskaya
• Journal: Likars'ka sprava (Lik Sprava) 2015 Oct-Dec Issue 7-8 Pg. 132-41 ISSN: 1019-5297 [Print] Ukraine
• PMID: 27491166 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Antihypertensive Agents
• GABA Agonists
• Nootropic Agents
• Nebivolol
• gamma-Aminobutyric Acid
• 4-amino-3-phenylbutyric acid

Topics

• Adolescent
• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Antihypertensive Agents (therapeutic use)
• Anxiety (drug therapy, physiopathology, psychology)
• Autonomic Nervous System (drug effects, physiopathology)
• Blood Pressure (drug effects)
• Blood Pressure Monitoring, Ambulatory
• Case-Control Studies
• Circadian Rhythm (physiology)
• Drug Administration Schedule
• Echocardiography, Doppler
• GABA Agonists (therapeutic use)
• Heart Rate (drug effects)
• Humans
• Hypertension (drug therapy, physiopathology, psychology)
• Male
• Nebivolol (therapeutic use)
• Nootropic Agents (therapeutic use)
• Surveys and Questionnaires
• gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)