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Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity.

Abstract
Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to overcome cancer cell resistance to therapy.
AuthorsRoman Uzhachenko, Anil Shanker
JournalOncoimmunology (Oncoimmunology) Vol. 5 Issue 5 Pg. e1122864 (May 2016) ISSN: 2162-4011 [Print] United States
PMID27467934 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

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