Abstract |
Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to overcome cancer cell resistance to therapy.
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Authors | Roman Uzhachenko, Anil Shanker |
Journal | Oncoimmunology
(Oncoimmunology)
Vol. 5
Issue 5
Pg. e1122864
(May 2016)
ISSN: 2162-4011 [Print] United States |
PMID | 27467934
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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