Abstract |
The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.
|
Authors | Leila Akkari, Johanna A Joyce |
Journal | Cell research
(Cell Res)
Vol. 26
Issue 8
Pg. 867-8
(08 2016)
ISSN: 1748-7838 [Electronic] England |
PMID | 27349476
(Publication Type: Journal Article, Comment)
|
Chemical References |
|
Topics |
- Cisplatin
- Drug Resistance, Neoplasm
- Female
- Glutathione
- Humans
- Ovarian Neoplasms
- T-Lymphocytes
- Tumor Microenvironment
|