HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Microenvironmental InterFereNce of metabolism regulates chemosensitivity.

Abstract
The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.
AuthorsLeila Akkari, Johanna A Joyce
JournalCell research (Cell Res) Vol. 26 Issue 8 Pg. 867-8 (08 2016) ISSN: 1748-7838 [Electronic] England
PMID27349476 (Publication Type: Journal Article, Comment)
Chemical References
  • Glutathione
  • Cisplatin
Topics
  • Cisplatin
  • Drug Resistance, Neoplasm
  • Female
  • Glutathione
  • Humans
  • Ovarian Neoplasms
  • T-Lymphocytes
  • Tumor Microenvironment

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: