Clinic and Home Blood Pressure Lowering Effect of an Angiotensin Receptor Blocker, Fimasartan, in Postmenopausal Women with Hypertension.

Abstract

Angiotensin receptor blockers may be an appropriate first-line agent for postmenopausal women with hypertension because the activation of renin-angiotensin-aldosterone system is suggested as one possible mechanism of postmenopausal hypertension. However, there are few studies substantiating this effect. This study aimed to investigate clinic and home blood pressure (BP) lowering effect of fimasartan, a new angiotensin receptor blocker, in postmenopausal women with hypertension.Among patients with hypertension enrolled in K-Mets Study, 1373 women with fimasartan as a first antihypertensive drug and 3-months follow-up data were selected. They were divided into 2 groups; premenopausal women (pre-MPW; n = 382, 45.3 ± 4.6 years) and postmenopausal women (post-MPW; n = 991, 60.9 ± 8.2 years).Baseline clinic systolic BP was not different (pre-MPW; 152.9 ± 15.2 vs. post-MPW; 152.8 ± 13.5 mm Hg), but diastolic BP was lower in post-MPW (pre-MPW; 95.7 ± 9.4 vs. post-MPW; 91.9 ± 9.4 mm Hg, P <0.001). After 3-month treatment, clinic BP declined effectively without significant differences between 2 groups (Δsystolic/diastolic BP: pre-MPW; -25.7 ± 17.7/-14.2 ± 11.3 vs. post-MPW; -25.7 ± 16.3/-13.1 ± 10.9 mm Hg). Home morning and evening systolic BP decreased similarly in both groups (Δmorning/evening systolic BP: pre-MPW; -21.3 ± 17.9/-23.1 ± 15.8 vs. post-MPW; -20.4 ± 17.3/-20.2 ± 19.2 mm Hg). Fimasartan also significantly decreased the standard deviations of home morning and evening systolic BP of pre-MPW and post-MPW.Fimasartan was a similarly effective BP lowering agent in both post-MPW and pre-MPW with hypertension, and it also decreased day-to-day BP variability.

• Authors: Song-Yi Kim, Seung-Jae Joo, Mi-Seung Shin, Changsoo Kim, Eun Joo Cho, Ki-Chul Sung, Seok-Min Kang, Dong-Soo Kim, Seung Hwan Lee, Kyung-Kuk Hwang, Jeong Bae Park
• Journal: Medicine (Medicine (Baltimore)) Vol. 95 Issue 22 Pg. e3764 (May 2016) ISSN: 1536-5964 [Electronic] United States
• PMID: 27258507 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Angiotensin Receptor Antagonists
• Antihypertensive Agents
• Biphenyl Compounds
• Pyrimidines
• Tetrazoles
• fimasartan

Topics

• Adult
• Aged
• Ambulatory Care Facilities (statistics & numerical data)
• Angiotensin Receptor Antagonists (adverse effects, therapeutic use)
• Antihypertensive Agents (adverse effects, therapeutic use)
• Biphenyl Compounds (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Blood Pressure Monitoring, Ambulatory (statistics & numerical data)
• Female
• Hospitals, University
• Humans
• Hypertension (drug therapy)
• Middle Aged
• Postmenopause
• Prospective Studies
• Pulse
• Pyrimidines (adverse effects, therapeutic use)
• Republic of Korea
• Tetrazoles (adverse effects, therapeutic use)