Abstract | BACKGROUND AND OBJECTIVES: The purpose of this study was to determine the pattern and timing of major wound complications (MWCs) in patients at our institution who received multimodality treatment for lower extremity soft tissue sarcoma (LE-STS) and to evaluate the impact of MWCs on tumor control and patient outcomes. METHODS: RESULTS: MWCs occurred in 22% of patients, with 45% of events occurring >120 days after resection. On multivariate analysis, preoperative external beam radiation therapy (EBRT) (OR 4.29, 95% CI 1.06-17.40, P = 0.042) and skin graft placement (OR 6.39, 95% CI 1.37-29.84, P = 0.018) were found to be independent predictors of MWCs. MWC occurrence did not predict for chronic toxicity and did not impact tumor control or survival. CONCLUSIONS: A considerable proportion of MWCs occur >120 days from surgical resection with preoperative EBRT and skin graft placement independent predictors for MWCs. While an additional source of morbidity, MWC occurrence did not impact tumor control, nor did it predict for chronic toxicity. J. Surg. Oncol. 2016;114:385-391. © 2016 Wiley Periodicals, Inc.
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Authors | Eric D Miller, Xiaokui Mo, Nicole T Andonian, Karl E Haglund, Douglas D Martin, David A Liebner, James L Chen, Obiajulu H Iwenofu, Arnab Chakravarti, Thomas J Scharschmidt, Joel L Mayerson, Raphael E Pollock, Meng Xu-Welliver |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 114
Issue 3
Pg. 385-91
(Sep 2016)
ISSN: 1096-9098 [Electronic] United States |
PMID | 27238092
(Publication Type: Journal Article)
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Copyright | © 2016 Wiley Periodicals, Inc. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Combined Modality Therapy
- Female
- Humans
- Lower Extremity
- Male
- Middle Aged
- Postoperative Complications
(epidemiology, pathology, therapy)
- Retrospective Studies
- Risk Factors
- Sarcoma
(mortality, therapy)
- Soft Tissue Neoplasms
(mortality, therapy)
- Time Factors
- Treatment Outcome
- Young Adult
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