Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension.

Abstract

BACKGROUND:

The angiotensin receptor antagonist fimasartan lowered blood pressure (BP) in a previous large population study. The purpose of this study was to evaluate whether fimasartan treatment for 3 months affects clinical and home BP variability in addition to reducing BP.

METHODS:

The study enrolled 1,396 patients (mean age 56.2±10.0 years; males 53.6%) with mild-to-moderate hypertension who had a complete set of home BP measurements (morning and evening) and metabolic risk evaluation. During the 3 months of study, fimasartan alone was used to control BP at a daily dose of 30-120 mg. Clinical and home BP measurements were performed before and after the 3-month treatment. BP variability included beat-to-beat variability (clinical) and day-to-day variability (home).

RESULTS:

Fimasartan reduced BP after 3 months of treatment. The average reduction of clinical systolic BP (c-SBP) was 15.08±18.36 mmHg (P<0.0001), and the average reduction of morning home SBP (m-SBP) was 11.49±19.33 mmHg (P<0.0001). Beat-to-beat variability as standard deviation (SD) of c-SBP was reduced from 4.56±3.22 to 4.24±3.11 mmHg (P=0.0026). Day-to-day variability as SD of m-SBP was reduced from 7.92±6.74 to 6.95±4.97 mmHg (P<0.0001). Multiple regression analysis revealed an independent association between the change in the SD of c-SBP and the change in c-SBP (P=0.0268) and, similarly, between the change in the SD of m-SBP and the change in m-SBP (P=0.0258), after adjusting for age, sex, body mass index, and change in mean BP.

CONCLUSION:

This study indicated that 3 months of fimasartan treatment reduced day-to-day BP variability independent of BP reduction in patients with hypertension.

• Authors: Mi-Seung Shin, Dae Ryong Kang, Changsoo Kim, Eun Joo Cho, Ki-Chul Sung, Seok-Min Kang, Dong-Soo Kim, Seung Jae Joo, Seung Hwan Lee, Kyung-Kuk Hwang, Jeong Bae Park
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 10 Pg. 1573-80 ( 2016) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 27217724 (Publication Type: Journal Article)

Chemical References

• Angiotensin Receptor Antagonists
• Antihypertensive Agents
• Biphenyl Compounds
• Pyrimidines
• Tetrazoles
• fimasartan

Topics

• Angiotensin Receptor Antagonists (chemistry, therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Biphenyl Compounds (chemistry, pharmacology)
• Blood Pressure (drug effects)
• Humans
• Hypertension (drug therapy)
• Pyrimidines (chemistry, pharmacology)
• Tetrazoles (chemistry, pharmacology)