Eccrine poromas arise from the intraepidermal region of the eccrine sweat duct and most often occur as a benign solitary
tumor. There are few reports of the occurrence of multiple lesions, defined as
poromatosis, which may present in patients who have undergone
radiotherapy and/or
polychemotherapy. We report the case of a 43-year-old male with a history of
mantle cell lymphoma who had undergone 6 cycles of
polychemotherapy. He presented to the dermatology clinic for multiple painful lesions on his palms and soles. Several biopsies were performed consistent with
eccrine poromas. The patient was successfully treated with a combination of excision,
imiquimod cream, and
cryosurgery. This case adds to the literature regarding the pathogenesis and treatment options of eccrine
poromatosis. Herein, we report a case of eccrine
poromatosis that developed after 6 cycles of
chemotherapy.