STC1 and NF-κB p65 (Rel A) is Constitutively Activated in Colorectal Cancer.

Abstract

BACKGROUND:

Stanniocalcin-1 (STC1) and nuclear factor (NF)-κB subunit p65 transcription factor are involved in various types of human malignancies. The roles of STC1 and NFκB-p65 in colorectal cancer (CRC) are still not fully understood. We investigated expression levels of NF-κB p65 and STC1 and also correlations between STC1 and NF-κB p65 expression and clinicopathological features in CRC.

METHODS:

Tumor tissue samples were collected from 48 patients with CRC. RT-PCR and Real-time PCR analysis was performed to examine mRNA levels of STC1 and NF-κB p65.

RESULTS:

The relative mRNA levels of STC1 and NF-κB p65 were significantly higher in tumor tissues than in adjacent mucosa (p = 0.025 and p = 0.044, respectively). The data also showed that STC1 and NF-κB p65 mRNA levels were not significantly associated with clinicopathological characteristics. In addition, there was no association between expression levels of STC1 and NF-κB p65 in tumor samples.

CONCLUSIONS:

Our data indicate that STC1 and NF-κBp65 is activated constitutively in colorectal carcinoma tissues, suggesting that activation of these factors might play an important role in colorectal tumorigenesis. Future studies should examine STC1 and NF-κBp65 as a molecular target for the treatment of CRC.

• Authors: Saleheh Rezapour, Tayyeb Bahrami, Shahryar Hashemzadeh, Mehrdad Asghari Estiar, Masoumeh Nemati, Reyhaneh Ravanbakhsh, Mohammad Ali Hosseinpour Feizi, Hossein Samadi Kafil, Nasser Pouladi, Morteza Ghojazadeh, Ebrahim Sakhinia
• Journal: Clinical laboratory (Clin Lab) Vol. 62 Issue 3 Pg. 463-9 ( 2016) ISSN: 1433-6510 [Print] Germany
• PMID: 27156337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycoproteins
• RNA, Messenger
• Transcription Factor RelA
• teleocalcin

Topics

• Adult
• Aged
• Colorectal Neoplasms (etiology, metabolism, pathology)
• Female
• Glycoproteins (genetics)
• Humans
• Male
• Middle Aged
• RNA, Messenger (analysis)
• Transcription Factor RelA (genetics)