[Alpha-Radioimmunotherapy: principle and relevance in anti-tumor immunity].

Abstract

Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastases. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and opens the way for development of new therapies combining α-RIT and different types of immunotherapy.

• Authors: Jérémie Ménager, Jean-Baptiste Gorin, Nolwenn Fichou, Sébastien Gouard, Alfred Morgenstern, Frank Bruchertseifer, François Davodeau, Françoise Kraeber-Bodéré, Michel Chérel, Joëlle Gaschet, Yannick Guilloux
• Journal: Medecine sciences : M/S (Med Sci (Paris)) Vol. 32 Issue 4 Pg. 362-9 (Apr 2016) ISSN: 1958-5381 [Electronic] France
• Vernacular Title: Radio-immunothérapie alpha - Principes et intérêts en immunité antitumorale.
• PMID: 27137693 (Publication Type: Journal Article, Review)
• Copyright: © 2016 médecine/sciences – Inserm.

Topics

• Alpha Particles (therapeutic use)
• Animals
• Humans
• Immune System (physiology, radiation effects)
• Neoplasms (immunology, radiotherapy)
• Radioimmunotherapy (methods)