Abstract | WHAT IS KNOWN AND OBJECTIVE:
Heart failure remains a leading cause of morbidity and mortality worldwide. Advanced therapies have prolonged survival in patients with advanced heart failure, but pharmacotherapeutic optimization remains the mainstay of treatment. It has been over 10 years since the last mortality-reducing medication has been approved by the Food and Drug Administration. This article reviews the background, current knowledge and data supporting the use of sacubitril/valsartan ( Entresto(®) ), the newly FDA-approved medication that dually inhibits angiotensin and neprilysin, in the treatment of heart failure. METHODS: A literature search was performed (January 1980 to August 2015) using PubMed and the search terms were as follows: neprilysin inhibitor, heart failure, endopeptidase, natriuretic peptides, angiotensin, omapatrilat, LCZ696, valsartan and sacubitril. Peer-reviewed, published clinical trials, review articles, relevant treatment guidelines and prescribing information documents were identified and reviewed for relevance. Additionally, reference citations from publications identified were reviewed. RESULTS AND DISCUSSION: WHAT IS NEW AND CONCLUSION:
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Authors | A J Ansara, D M Kolanczyk, J M Koehler |
Journal | Journal of clinical pharmacy and therapeutics
(J Clin Pharm Ther)
Vol. 41
Issue 2
Pg. 119-27
(Apr 2016)
ISSN: 1365-2710 [Electronic] England |
PMID | 26992459
(Publication Type: Journal Article, Review)
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Copyright | © 2016 John Wiley & Sons Ltd. |
Chemical References |
- Aminobutyrates
- Angiotensin Receptor Antagonists
- Angiotensins
- Biphenyl Compounds
- Drug Combinations
- Tetrazoles
- Valsartan
- Neprilysin
- sacubitril and valsartan sodium hydrate drug combination
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Topics |
- Aminobutyrates
(therapeutic use)
- Angiotensin Receptor Antagonists
(therapeutic use)
- Angiotensins
(antagonists & inhibitors)
- Biphenyl Compounds
- Drug Combinations
- Heart Failure
(drug therapy)
- Humans
- Neprilysin
(antagonists & inhibitors)
- Tetrazoles
(therapeutic use)
- Valsartan
(therapeutic use)
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