Abstract | INTRODUCTION: METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation. RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI. CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.
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Authors | Tobias Bäumer, Alexander Schmidt, Marcus Heldmann, Moritz Landwehr, Anna Simmer, Diana Tönniges, Thomas Münte, Katja Lohmann, Eckart Altenmüller, Christine Klein, Alexander Münchau |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 25
Pg. 33-8
(Apr 2016)
ISSN: 1873-5126 [Electronic] England |
PMID | 26923523
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain
(physiopathology)
- Dystonic Disorders
(diagnosis, genetics, physiopathology)
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Pedigree
- Transcranial Magnetic Stimulation
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