Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females.

Abstract

OBJECTIVE:

This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline.

METHODS:

A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target.

RESULTS:

The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ≥2, and joint space narrowing ≥1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure.

CONCLUSION:

A reduction of ≥5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.

• Authors: Jos Runhaar, Bastiaan C de Vos, Marienke van Middelkoop, Dammis Vroegindeweij, Edwin H G Oei, Sita M A Bierma-Zeinstra
• Journal: Arthritis care & research (Arthritis Care Res (Hoboken)) Vol. 68 Issue 10 Pg. 1428-33 (10 2016) ISSN: 2151-4658 [Electronic] United States
• PMID: 26866630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016, American College of Rheumatology.

Chemical References

• Glucosamine

Topics

• Body Weight
• Diet, Reducing (methods)
• Exercise Therapy (methods)
• Female
• Glucosamine (therapeutic use)
• Humans
• Middle Aged
• Obesity (complications)
• Osteoarthritis, Knee (etiology, prevention & control)
• Overweight (complications)
• Risk Factors
• Treatment Outcome
• Weight Loss