Abstract | BACKGROUND: METHODS: Adult patients scheduled for elective surgery for supratentorial tumors were randomized to receive a 10-minute intraoperative DEX infusion of 0.4 μg/kg (small dose, n=43) or 0.8 μg/kg (medium dose, n=46), or normal saline (vehicle control, n=45), ∼60 minutes before the end of anesthesia. RESULTS: A transient increase in the blood pressure associated with DEX was observed; 53.5% and 91.3% of the patients in the small-dose and the medium-dose groups, respectively, required treatment. Emergence mean arterial pressure and heart rates were significantly lower in the DEX groups compared with the control group. Incidence rates of postoperative hypertension in the small-dose (16.3%) and the medium-dose groups (15.2%) were significantly lower relative to that of the control group (35.6%). Patients who received DEX had a lower Verbal Numerical Rating Scale (VNRS) score in the neurosurgical ICU than the control group, and postsurgical pain (VNRS≥4) was lower in the medium-dose group (41.3%) than in the control group (71.1%). No shivering was observed in the medium-dose group, which was significantly less than that of the other 2 groups. CONCLUSIONS: An intraoperative bolus of DEX risks a transient increase in mean arterial pressure, but controls emergence hypertension effectively. Dose-related reductions in postsurgical pain and shivering were observed.
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Authors | Yue Yun, Jian Wang, Ru Rong Tang, Xiu Ru Yin, Heng Zhou, Ling Pei |
Journal | Journal of neurosurgical anesthesiology
(J Neurosurg Anesthesiol)
Vol. 29
Issue 3
Pg. 211-218
(Jul 2017)
ISSN: 1537-1921 [Electronic] United States |
PMID | 26859547
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Dexmedetomidine
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Topics |
- Adult
- Aged
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects, therapeutic use)
- Arterial Pressure
(drug effects)
- Blood Pressure
(drug effects)
- Craniotomy
(adverse effects)
- Dexmedetomidine
(administration & dosage, adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(epidemiology)
- Incidence
- Intraoperative Care
(methods)
- Male
- Middle Aged
- Pain, Postoperative
(epidemiology, prevention & control)
- Postoperative Complications
(chemically induced, epidemiology)
- Prospective Studies
- Shivering
(drug effects)
- Supratentorial Neoplasms
(surgery)
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