Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report.

Abstract

INTRODUCTION:

Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonal tumor of the central nervous system with a generally dismal prognosis, especially in patients younger than 12 months.

DISCUSSION:

We here describe the unusual case of an infant with AT/RT with long-term survival despite low-cumulative dose chemotherapy after subtotal resection. Due to a poor neurological situation and an unfavorable oncological prognosis, therapy was halted after two partial surgical resections and four of the nine chemotherapy courses recommended by the European Rhabdoid Registry, without the patient receiving either radiotherapy or high-dose chemotherapy. The patient is alive without evidence of disease 52 months after diagnosis.

CONCLUSION:

This case report highlights that independent prognostic factors are urgently needed for optimizing treatment stratification and preventing overtreatment.

• Authors: Viktor Arnhold, Florian Oyen, Reinhard Schneppenheim, Hannes Haberl, Arend Koch, Michael C Frühwald, Pablo Hernáiz Driever
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 32 Issue 6 Pg. 1157-61 (Jun 2016) ISSN: 1433-0350 [Electronic] Germany
• PMID: 26747622 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (therapeutic use)
• Brain Neoplasms (drug therapy, surgery)
• Combined Modality Therapy
• Female
• Humans
• Infant
• Magnetic Resonance Imaging
• Neurosurgical Procedures (methods)
• Rhabdoid Tumor (drug therapy, mortality, surgery)