EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment.

Abstract

AIM:

Development of epigallocatechin gallate (EGCG) and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) for fluorescence imaging and inhibition of prostate cancer cell growth.

MATERIALS & METHODS:

AuNPs alternatively coated with EGCG and DOX-GLT conjugates were prepared by a layer-by-layer assembly method. The physicochemical properties of the AuNPs and the effect of Laminin 67R receptor-mediated endocytosis on the anticancer efficacy of the AuNPs were examined.

RESULTS:

The AuNPs significantly inhibit the proliferation of PC-3 cancer cell and the enzyme-responsive intracellular release of DOX could be tracked by monitoring the recovery of the fluorescence signal of DOX.

CONCLUSION:

Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.

• Authors: Li-Chu Tsai, Hao-Ying Hsieh, Kun-Ying Lu, Sin-Yu Wang, Fwu-Long Mi
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 11 Issue 1 Pg. 9-30 (Jan 2016) ISSN: 1748-6963 [Electronic] England
• PMID: 26654241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Gold
• Doxorubicin
• Catechin
• Gelatin
• epigallocatechin gallate

Topics

• Antibiotics, Antineoplastic (administration & dosage, chemistry)
• Catechin (analogs & derivatives, chemistry)
• Cell Line, Tumor
• Doxorubicin (administration & dosage, chemistry)
• Gelatin (chemistry)
• Gold (chemistry)
• Humans
• Male
• Metal Nanoparticles