In vitro activity of ceftaroline against staphylococci from prosthetic joint infection.

Abstract

We tested the in vitro activity of ceftaroline by Etest against staphylococci recovered from patients with prosthetic joint infection, including 97 Staphylococcus aureus isolates (36%, oxacillin resistant) and 74 Staphylococcus epidermidis isolates (74%, oxacillin resistant). Ceftaroline inhibited all staphylococci at ≤0.5 μg/mL. The ceftaroline MIC(90/50) values for methicillin-susceptible S. aureus, methicillin-susceptible S. epidermidis, methicillin-resistant S. aureus, and methicillin-resistant S. epidermidis were 0.19/0.125, 0.094/0.047, 0.5/0.38, and 0.38/0.19 μg/mL, respectively. Based on these in vitro findings, ceftaroline should be further evaluated as a potential therapeutic option for the treatment of prosthetic joint infection caused by methicillin-susceptible and methicillin-resistant S. aureus and S. epidermidis.

• Authors: Kyung-Hwa Park, Kerryl E Greenwood-Quaintance, Robin Patel
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 84 Issue 2 Pg. 141-3 (Feb 2016) ISSN: 1879-0070 [Electronic] United States
• PMID: 26602948 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Cephalosporins

Topics

• Anti-Bacterial Agents (pharmacology)
• Arthritis (microbiology)
• Cephalosporins (pharmacology)
• Disk Diffusion Antimicrobial Tests
• Humans
• Prosthesis-Related Infections (microbiology)
• Staphylococcal Infections (microbiology)
• Staphylococcus aureus (drug effects, isolation & purification)
• Staphylococcus epidermidis (drug effects, isolation & purification)
• Ceftaroline