Abstract | AIM: Intranasal corticosteroids (INS) have been proven effective in controlling postnasal drip, decreasing inflammatory response, reducing nasal swelling, and increasing aeration of the sinuses such that INS are recommended as treatment of sinusitis. METHODS: Fifty children with acute rhinosinusitis, 50 children with acute rhiniosinusitis and allergic rhinitis (AR), and 20 rhiniosinusitis children as control were selected for investigation. Each group had a single-blind treatment of three types: with coamoxiclav only, with coamoxiclav plus INS, and with matched placebo (without antibiotics and INS) for two weeks. Nasal symptoms were then evaluated. The outcome was measured by using major symptom score (MSS) after treatment for 14 days. RESULTS: Therapeutic effectiveness was 92% in rhinosinusitis patients treated with co-amoxiclav and 84% in those treated with co-amoxiclav plus INS. Among patients with sinusitis combined with AR, therapeutic efficacy was 88% for those treated with co-amoxiclav and 96% for those treated with co-amoxiclav plus INS. Only 30% of the symptoms were reduced in the placebo group. CONCLUSION:
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Authors | K S Wan, W F Wu, T C Chen, C S Wu, C W Hung, Y S Chang |
Journal | Minerva pediatrica
(Minerva Pediatr)
Vol. 67
Issue 6
Pg. 489-94
(Dec 2015)
ISSN: 1827-1715 [Electronic] Italy |
PMID | 26530491
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Allergic Agents
- Anti-Bacterial Agents
- Amoxicillin-Potassium Clavulanate Combination
- Fluticasone
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Topics |
- Acute Disease
- Administration, Intranasal
- Adolescent
- Amoxicillin-Potassium Clavulanate Combination
(administration & dosage, therapeutic use)
- Anti-Allergic Agents
(administration & dosage, therapeutic use)
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Female
- Fluticasone
(administration & dosage, therapeutic use)
- Humans
- Male
- Rhinitis
(drug therapy)
- Rhinitis, Allergic
(drug therapy)
- Single-Blind Method
- Sinusitis
(drug therapy)
- Treatment Outcome
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