Filgrastim versus TBO-filgrastim to reduce the duration of neutropenia after autologous hematopoietic stem cell transplantation: TBO, or not TBO, that is the question.
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| Abstract |
After a hospital-wide formulary change resulted in the replacement of filgrastim with TBO-filgrastim for all on- and off-label indications, we performed a retrospective comparison of patients with myeloma receiving 200 mg/m(2) melphalan with autologous hematopoietic stem cell transplantation to see whether the type of growth factor used post-transplant made a difference. One hundred and eighty-two consecutive patients with myeloma were studied, 91 receiving filgrastim immediately prior to the change and 91 receiving TBO-filgrastim afterward. The CD34(+) cell dose was comparable, as were other characteristics. Although the overall time to neutrophil recovery was similar for both groups, early engraftment (≤ 12 d) occurred more often (p = 0.05), and late engraftment (≥ 14 d) less often (p = 0.09) in filgrastim-treated patients. The number of documented infections was significantly less in the TBO-filgrastim group. Day 100 mortality and hospital stay were similar for the two groups. These data indicate that there is no material difference between filgrastim and TBO-filgrastim in this clinical setting.
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| Authors | Steven Trifilio, Zheng Zhou, John Galvin, Jessica L Fong, Joanne Monreal, Jayesh Mehta |
| Journal | Clinical transplantation (Clin Transplant) Vol. 29 Issue 12 Pg. 1128-32 (Dec 2015) ISSN: 1399-0012 [Electronic] Denmark |
| PMID | 26493022 (Publication Type: Comparative Study, Journal Article) |
| Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
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