Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata.

Abstract

The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.

• Authors: Pamela Thomson, Josep Guarro, Emilio Mayayo, Javier Capilla
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 12 Pg. 7477-82 (Dec 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 26392490 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Antifungal Agents
• Proteoglycans
• Triazoles
• beta-Glucans
• polysaccharide-K
• posaconazole

Topics

• Animals
• Antifungal Agents (administration & dosage, blood, pharmacology)
• Basidiomycota (drug effects, isolation & purification, pathogenicity)
• Brain (drug effects, microbiology, pathology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Immunocompromised Host
• Kidney (drug effects, microbiology, pathology)
• Male
• Mice, Inbred Strains
• Microbial Sensitivity Tests
• Mycoses (drug therapy, microbiology, mortality)
• Neutropenia (microbiology)
• Proteoglycans
• Triazoles (administration & dosage, blood, pharmacology)
• beta-Glucans (blood)