Abstract | PURPOSE: The efficacy and safety of stereotactic radiosurgery (SRS) for treatment of intracranial meningiomas has been demonstrated in numerous studies with short- and intermediate-term follow-up. In this retrospective single-center study, we present long-term outcomes of SRS performed with a linear accelerator (LINAC) for typical intracranial meningiomas. PATIENTS AND METHODS: Between August 1990 and December 2007, 148 patients with 168 typical intracranial meningiomas were treated with stereotactic LINAC-SRS, either as primary treatment or after microsurgical resection. A median tumor surface dose of 12 Gy (range 7-20 Gy) and a median maximum dose of 24.1 Gy (range 11.3-58.6 Gy) was applied. The median target volume was 4.7 ml (range 0.2-32.8 ml, SD ± 4.8 ml). RESULTS: Overall mean radiological follow-up was 12.6 years. Tumor shrinkage was seen in 75 (44.6 %) and stable disease in 85 (50.6 %) cases. Eight of 168 meningiomas (4.8 %) showed local tumor progression. The tumor control rate (TCR) after 5, 10, and 15 years was 93.6 % at each time point, and the progression-free survival (PSF) rates were 92, 89, and 89 %, respectively. The neurological symptoms existing prior to LINAC-SRS improved in 77 patients (59.7 %), remained unchanged in 42 (32.6 %), and deteriorated in 10 (7.8 %) patients. CONCLUSION: Our study emphasizes the efficacy of LINAC-SRS for de novo, residual and recurrent typical intracranial meningiomas. A high long-term local TCR with a low morbidity rate could be achieved. LINAC-SRS should thus be considered as a primary treatment option, as one arm of a combined treatment approach for incompletely resected meningiomas, or as a salvage therapy for recurrences.
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Authors | Mustafa El-Khatib, Faycal El Majdoub, Stefan Hunsche, Mauritius Hoevels, Martin Kocher, Volker Sturm, Mohammad Maarouf |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 191
Issue 12
Pg. 921-7
(Dec 2015)
ISSN: 1439-099X [Electronic] Germany |
PMID | 26253788
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Combined Modality Therapy
- Disease-Free Survival
- Female
- Follow-Up Studies
- Germany
- Humans
- Male
- Meningeal Neoplasms
(diagnosis, surgery)
- Meningioma
(diagnosis, surgery)
- Microsurgery
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis, surgery)
- Neoplasm, Residual
(diagnosis, surgery)
- Neurologic Examination
- Postoperative Complications
(diagnosis)
- Radiosurgery
- Reoperation
- Treatment Outcome
- Young Adult
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