Abstract | OBJECTIVE: METHOD: RESULT: The initial symptoms developed 3 months after his birth, multiple systems (skin, skeleton, lung, liver) were involved; he was sequentially treated with LCH-III-Group I, JLSG-96, DAL-HX90 chemotherapeutic regimens. The patient got relapses for more than 3 times, but the disease got completely controlled after being treated with cladribine when the patient was 6 years old. The dosage was 10 mg/(m2 · d) for 4 days, and one course lasted for 28 days, the third to fifth courses of treatment used Arac in combination, the whole treating time lasted for 5 months. The patient remained in persistent remission for 8 months since discontinuation of treatment. " Langerhans cell histiocytosis" "refractory" " cladribine" were used as the key words to search in the data bases CNKI, Wanfangdata and Pubmed, 11 articles were picked. According to the literature, the effective rate of cladribine in treatment of repeatedly relapsing Langerhans cell histiocytosis was 44%-100%, with a good response of 22%-86%, the dose was 5-13 mg/(m2 · d). The main side effects were hematological system damages and infection. CONCLUSION:
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Authors | Xie Yao, Hua Ying, Zhao Weihong, Sun Qing, Lu Xintian |
Journal | Zhonghua er ke za zhi = Chinese journal of pediatrics
(Zhonghua Er Ke Za Zhi)
Vol. 53
Issue 4
Pg. 296-9
(Apr 2015)
ISSN: 0578-1310 [Print] China |
PMID | 26182506
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Cladribine
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Topics |
- Child
- Cladribine
(therapeutic use)
- Histiocytosis, Langerhans-Cell
(drug therapy)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Recurrence
- Skin
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