Biofunctional properties of Eruca sativa Miller (rocket salad) hydroalcoholic extract.

Abstract

Eruca sativa Miller is a worldwide common alimentary plant (rocket leaves). The aim of this study was to correlate the potential in vitro scavenging activity of the E. sativa hydroalcoholic extract (HAE) with its in vivo hypoglycaemic effect. In DDPH free radical (DFR) and ferric-reducing antioxidant power assays, HAE in a concentration dependent manner (25-100 μg/mL) displayed a strong scavenging activity with maximum effect of 88% and 75% at 100 μg/mL, respectively. Daily administration of HAE (50 mg/kg; p.o.) in the in vivo model of alloxan-induced diabetic rabbits for 28 days showed significant reduction in glycaemia, also supported by recovery of body weight. In conclusion, our results give preliminary information on the potential use of this plant as a nutraceutical, useful to control and/or prevent a hyperglycaemic status.

• Authors: Khushbakht Sultan, Muhammad Zakir, Haroon Khan, Abdur Rauf, Noor Ul Akber, Murad Ali Khan
• Journal: Natural product research (Nat Prod Res) Vol. 30 Issue 10 Pg. 1202-4 ( 2016) ISSN: 1478-6427 [Electronic] England
• PMID: 26156861 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Free Radical Scavengers
• Hypoglycemic Agents
• Plant Extracts
• Alloxan

Topics

• Alloxan
• Animals
• Blood Glucose (analysis)
• Body Weight
• Brassicaceae (chemistry)
• Diabetes Mellitus, Experimental (chemically induced, drug therapy)
• Free Radical Scavengers (chemistry, isolation & purification)
• Hypoglycemic Agents (chemistry, isolation & purification)
• Plant Extracts (chemistry)
• Plant Leaves (chemistry)
• Rabbits