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Expression and prognostic significance of VEGFR-2 in breast cancer.

Abstract
Breast cancer is one of the most common cancers among women in the world. Vascular endothelial growth factor receptor 2 (VEGFR-2) was not only found to play a key role in the development of tumor angiogenesis, but has also been located in tumor cells of a variety of tumors. This study investigated the expression pattern of VEGFR-2 in breast cancer tissue specimens in order to evaluate the role of VEGFR-2 in the prognosis of breast cancer. Expression and localization of VEGFR-2 in tumor cells of breast cancer specimens from 98 invasive breast cancer patients were determined by immunohistochemistry. The relationships between VEGFR-2 expression and clinicopathological features were also analyzed. The results showed that VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer. Patients with high expression of VEGFR-2 had a significantly worse OS. It was also observed that the expression of epithelial-mesenchymal transition (EMT) marker, including Twist1 and Vimentin, was higher in the tumors with higher VEGFR-2 expression, while the E-cadherin expression was lower in the same tumors, suggesting that VEGFR-2 may serve as a possible mediator of EMT in breast cancer.
AuthorsJi-Dong Yan, Yanrong Liu, Zhi-Yong Zhang, Guang-Yin Liu, Jin-Heng Xu, Li-Yun Liu, Yue-Ming Hu
JournalPathology, research and practice (Pathol Res Pract) Vol. 211 Issue 7 Pg. 539-43 (Jul 2015) ISSN: 1618-0631 [Electronic] Germany
PMID25976977 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier GmbH. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • KDR protein, human
  • Vascular Endothelial Growth Factor Receptor-2
Topics
  • Adult
  • Aged
  • Biomarkers, Tumor (analysis)
  • Breast Neoplasms (mortality, pathology)
  • Carcinoma, Ductal, Breast (mortality, pathology)
  • Epithelial-Mesenchymal Transition (physiology)
  • Female
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis (pathology)
  • Middle Aged
  • Prognosis
  • Vascular Endothelial Growth Factor Receptor-2 (analysis, biosynthesis)

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