Abstract | BACKGROUND: METHODS: RESULTS: In patients not given an antiepileptic, we found no significant differences in the propofol dose, modeled propofol blood concentration at emergence, or time to emerge among patients with AU, CP, and ID (P > 0.05). When using an antiepileptic, the dose of propofol (5.7 ± 1.51 mg/kg/h) was significantly lower than without an antiepileptic (6.8 ± 1.27 mg/kg/h) (P < 0.0001). The modeled propofol blood concentration at emergence in patients given an antiepileptic (0.5 ± 0.03 μg/ml) was significantly lower than without an antiepileptic (0.7 ± 0.02 μg/ml) (P < 0.0001). The time to emerge in patients given an antiepileptic (29.5 ± 12.5 min) was significantly longer than without an antiepileptic (21.6 min ± 10.0 min) (P < 0.0001). CONCLUSION: TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry (UMIN000014179), Date of registration 4 June 2014.
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Authors | Kentaro Ouchi, Kazuna Sugiyama |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 15
Pg. 34
( 2015)
ISSN: 1471-2253 [Electronic] England |
PMID | 25788855
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Intravenous
- Anticonvulsants
- Propofol
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Topics |
- Adult
- Anesthesia Recovery Period
- Anesthetics, Intravenous
(administration & dosage, blood, pharmacology)
- Anticonvulsants
(pharmacology, therapeutic use)
- Autistic Disorder
(complications)
- Cerebral Palsy
(complications)
- Drug Interactions
- Epilepsy
(complications, drug therapy)
- Female
- Humans
- Intellectual Disability
(complications)
- Male
- Propofol
(administration & dosage, blood, pharmacology)
- Prospective Studies
- Stomatognathic Diseases
(complications)
- Young Adult
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