Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. METHODOLOGY: RESULT: CONCLUSION: Overall, aqueous extract of D. cumminsii leaves at all doses investigated reduced blood glucose level and prevented oxidative stress and dyslipidemia in alloxan-induced diabetic rats.
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Authors | H O B Oloyede, T O Bello, T O Ajiboye, M O Salawu |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 166
Pg. 313-22
(May 26 2015)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 25749145
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Hypolipidemic Agents
- Insulin
- Plant Extracts
- Alloxan
- Glyburide
|
Topics |
- Alloxan
(pharmacology)
- Animals
- Blood Glucose
(drug effects)
- Diabetes Mellitus, Experimental
(chemically induced, drug therapy, metabolism)
- Glyburide
(pharmacology)
- Hypoglycemic Agents
(pharmacology)
- Hypolipidemic Agents
(chemistry, pharmacology)
- Insulin
(metabolism)
- Liver
(drug effects, metabolism)
- Male
- Menispermaceae
(chemistry)
- Oxidative Stress
(drug effects)
- Pancreas
(metabolism)
- Phytotherapy
(methods)
- Plant Extracts
(chemistry, pharmacology)
- Plant Leaves
(chemistry)
- Rats
- Rats, Wistar
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