Abstract | INTRODUCTION: AREAS COVERED: This article reviews the current literature on blinatumomab including its pharmacology, preclinical findings, clinical trials in B-cell NHL and, to a lesser extent, Phase II studies in B-ALL. The authors discuss the potential future directions in light of other new competing therapies for NHL and unmet clinical needs in the market. EXPERT OPINION: The recent approval of blinatumomab for B-ALL symbolizes a breakthrough for BiTE technology with prospective application in the targeted therapy of other cancers. Although blinatumomab seems an unlikely option for treating indolent lymphoma due to toxicity, the need for long-term continuous infusion therapy and multiple promising well-tolerated oral agents, it holds promise for aggressive NHL patients whose diseases are refractory to current standard approaches. Larger trials are needed to demonstrate blinatumomab's curative potential in aggressive histologies.
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Authors | Eunhye Oak, Nancy L Bartlett |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 24
Issue 5
Pg. 715-24
(May 2015)
ISSN: 1744-7658 [Electronic] England |
PMID | 25739952
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies, Bispecific
- Antineoplastic Agents
- blinatumomab
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Topics |
- Antibodies, Bispecific
(adverse effects, pharmacology, therapeutic use)
- Antineoplastic Agents
(adverse effects, pharmacology, therapeutic use)
- Humans
- Lymphoma, B-Cell
(drug therapy, pathology)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy, pathology)
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