Anticancer properties of lamellarins.

Abstract

In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than 50 lamellarins have been inventoried and numerous derivatives synthesized and tested as antiviral or anticancer agents. The lead compound in the family is lamellarin D, characterized as a potent inhibitor of both nuclear and mitochondrial topoisomerase I but also capable of directly interfering with mitochondria to trigger cancer cell death. The pharmacology and chemistry of lamellarins are discussed here and the mechanistic portrait of lamellarin D is detailed. Lamellarins frequently serve as a starting point in the design of anticancer compounds. Extensive efforts have been devoted to create novel structures as well as to improve synthetic methods, leading to lamellarins and related pyrrole-derived marine alkaloids.

• Authors: Christian Bailly
• Journal: Marine drugs (Mar Drugs) Vol. 13 Issue 3 Pg. 1105-23 (Feb 19 2015) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 25706633 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Coumarins
• Heterocyclic Compounds, 4 or More Rings
• Isoquinolines
• lamellarin D

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Death (drug effects)
• Coumarins (chemistry, isolation & purification, pharmacology)
• Drug Design
• Heterocyclic Compounds, 4 or More Rings (chemistry, isolation & purification, pharmacology)
• Humans
• Isoquinolines (chemistry, isolation & purification, pharmacology)
• Mitochondria (drug effects)
• Mollusca (chemistry)
• Neoplasms (drug therapy)
• Structure-Activity Relationship