Feasibility of image-guided radiotherapy and concurrent chemotherapy for locally advanced nonsmall cell lung cancer.

Abstract

A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.

• Authors: Nam P Nguyen, Sarah Kratz, Alexander Chi, Jacqueline Vock, Paul Vos, Wei Shen, Vinh-Hung Vincent, Lars Ewell, Siyoung Jang, Gabor Altdorfer, Ulf Karlsson, Juan Godinez, William Woods, Suresh Dutta, Fred Ampil, International Geriatric Radiotherapy Group
• Journal: Cancer investigation (Cancer Invest) Vol. 33 Issue 3 Pg. 53-60 (Mar 2015) ISSN: 1532-4192 [Electronic] England
• PMID: 25634242 (Publication Type: Journal Article)

Topics

• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology, radiotherapy)
• Chemoradiotherapy
• Female
• Humans
• Lung Neoplasms (drug therapy, pathology, radiotherapy)
• Male
• Middle Aged
• Radiotherapy, Image-Guided (methods)
• Retrospective Studies
• Survival Analysis