Abstract |
Resistant starch (RS) is a dietary fermentable fiber that decreases body fat accumulation, and stimulates the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in rodents. GLP-1 and PYY are gut-secreted hormones with antiobesity effect. Thus, blocking the signals of increased GLP-1 and PYY may also block the effect of dietary RS on body fat. In a 10-week study, C57BL/6J and GLP-1 receptor null (GLP-1R KO) mice were fed control or 30% RS diet, and received daily intraperitoneal injection of either saline or PYY receptor antagonist ( BIIE0246, 20 μg/kg body weight). Dietary RS significantly decreased body fat accumulation only in wild-type mice that has saline injection, but not in GLP-1R KO mice. PYY receptor antagonist diminished RS action on body fat in wild-type mice, but did not interfere with GLP-1R KO mice response to RS. Regardless of genotype and injection received, all RS-fed mice had increased cumulative food intake, cecal fermentation, and mRNA expression of proglucagon and PYY. Thus, our results suggest that increased GLP-1 and PYY is important in RS effects on body fat accumulation.
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Authors | June Zhou, Roy J Martin, Anne M Raggio, Li Shen, Kathleen McCutcheon, Michael J Keenan |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 59
Issue 5
Pg. 1000-3
(May 2015)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 25631638
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Dietary Fiber
- Peptide YY
- Glucagon-Like Peptide 1
- Starch
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Topics |
- Adipose Tissue
(metabolism)
- Animals
- Dietary Fiber
(pharmacology)
- Glucagon-Like Peptide 1
(blood, physiology)
- Mice
- Peptide YY
(blood, physiology)
- Starch
(pharmacology)
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