miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.

Abstract

This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

• Authors: W Y Lam, Ariel C Y Cheung, Christine K C Tung, Apple C M Yeung, Karry L K Ngai, Vivian W Y Lui, Paul K S Chan, Stephen K W Tsui
• Journal: FEBS letters (FEBS Lett) Vol. 589 Issue 2 Pg. 246-54 (Jan 16 2015) ISSN: 1873-3468 [Electronic] England
• PMID: 25497012 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• Clmp protein, rat
• Coxsackie and Adenovirus Receptor-Like Membrane Protein
• MIRN466 microRNA, human
• MIRN466 microRNA, rat
• MicroRNAs

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Cell Line
• Coxsackie and Adenovirus Receptor-Like Membrane Protein (chemistry, genetics)
• Enterovirus B, Human (metabolism)
• Gene Expression Regulation
• Humans
• MicroRNAs (genetics)
• Molecular Sequence Data
• Rats