Relationship of argyrophilic proteins of nucleolal organizer regions in Ki-67+ cells with clinical and morphological parameters in lung adenocarcinoma.

Abstract

Ninety-four lung adenocarcinoma samples obtained during surgeries were examined using a combination of immunohistochemical staining for Ki-67 antigen and silver nitrate staining for argyrophilic nucleolar organizer (Ag-NOR) proteins. In lung adenocarcinoma, we studied the correlation between the area of Ag-NOR proteins in Ki-67(+) cells and clinical and morphological TNM parameters: maximum tumor diameter (T) and stage of the disease and tumor differentiation degree (N). Survival of patients with small area of Ag-NOR proteins in Ki-67(+) cells was higher that in patients with great area of these proteins. The area of Ag-NOR proteins in Ki-67(+) cells is an independent prognostic factor in lung adenocarcinoma. The area of Ag-NOR proteins in Ki-67(+) cells correlates with clinical and morphological TNM parameters and survival of patients with lung adenocarcinoma.

• Authors: A F Lazarev, D S Kobyakov, A M Avdalyan, E L Lushnikova, L M Nepomnyashchikh
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 158 Issue 1 Pg. 145-9 (Nov 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 25408525 (Publication Type: Journal Article)

Chemical References

• Antigens, Nuclear
• Biomarkers, Tumor
• Ki-67 Antigen
• nucleolar organizer region associated proteins

Topics

• Adenocarcinoma (metabolism, mortality, pathology)
• Adenocarcinoma of Lung
• Adult
• Aged
• Antigens, Nuclear (metabolism)
• Biomarkers, Tumor (metabolism)
• Female
• Humans
• Kaplan-Meier Estimate
• Ki-67 Antigen (metabolism)
• Lung Neoplasms (metabolism, mortality, pathology)
• Male
• Middle Aged
• Nucleolus Organizer Region (metabolism)
• Proportional Hazards Models