Abstract |
The inbred Fischer (F344) and Lewis (LEW) rats, while originally developed as animal models for cancer and tissue transplantation research, have since been used to study genetic differences in a variety of physiological and behavioral endpoints. In this context, LEW rats show greater sensitivity to the aversive effects of cocaine as compared to F344 rats in a conditioned taste avoidance procedure. Like cocaine, 3,4-methylenedioxypyrovalerone ( MDPV; "bath salts") acts as a dopamine transport blocker and possesses aversive properties, making it a good candidate for assessing whether the aforementioned strain differences with cocaine would generalize to drugs with similar biochemical action. Accordingly, male F344 and LEW rats were exposed to a novel saccharin solution followed by injections of one of four doses of MDPV in a taste avoidance procedure. Over the four saccharin/ MDPV pairings during conditioning, core body temperatures were also assessed. Similar to previous research, MDPV induced robust dose-dependent taste avoidance, although no effect of strain was observed. MDPV also produced hyperthermia that was independent of strain and unrelated to the conditioned taste avoidance. These findings argue for a complex influence of multiple (and likely interacting) monoaminergic systems mediating MDPV-induced taste avoidance in the two strains and suggest different mechanisms of avoidance learning for cocaine and MDPV.
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Authors | Heather E King, Bradley Wetzell, Kenner C Rice, Anthony L Riley |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 126
Pg. 163-9
(Nov 2014)
ISSN: 1873-5177 [Electronic] United States |
PMID | 25284129
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014. Published by Elsevier Inc. |
Chemical References |
- Benzodioxoles
- Pyrrolidines
- Synthetic Cathinone
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Topics |
- Animals
- Avoidance Learning
(drug effects)
- Benzodioxoles
(pharmacology)
- Body Temperature
(drug effects)
- Conditioning, Psychological
(drug effects)
- Dose-Response Relationship, Drug
- Male
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Inbred F344
- Rats, Inbred Lew
- Species Specificity
- Taste
- Synthetic Cathinone
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