Extracorporeal complexation haemodialysis for the treatment of cadmium poisoning. II. In vivo mobilization and removal.

Abstract	The purpose of this study was to apply our earlier in vitro findings for extracorporeal complexation combined with haemodialysis to in vivo conditions, for the enhancement of cadmium (Cd) removal from dogs. The results showed that ethylenediaminetetraacetic acid (EDTA), glutathione (GSH) and combination of the two agents (EDTA + GSH) facilitated efficient elimination of cadmium. GSH, EDTA and EDTA + GSH treatments brought about the clearance of 2.2, 14.7 and 18.2 micrograms Cd/kg body weight/hr haemodialysis, respectively. Treatment with EDTA + GSH brought about the most rapid extravascular redistribution of the metal.
Authors	F Z Sheabar, S Yannai, U Taitelman
Journal	Pharmacology & toxicology (Pharmacol Toxicol) Vol. 65 Issue 1 Pg. 13-6 (Jul 1989) ISSN: 0901-9928 [Print] Denmark
PMID	2506542 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Chelating Agents Cadmium Edetic Acid Glutathione
Topics	Animals Cadmium (blood) Cadmium Poisoning (drug therapy) Chelating Agents (therapeutic use) Dogs Drug Therapy, Combination Edetic Acid (therapeutic use) Female Glutathione (therapeutic use) Male Renal Dialysis

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