Abstract | BACKGROUND: METHODS: A total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, 0.15 µg.kg-1 of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images. RESULTS: From the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups. CONCLUSIONS:
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Authors | Sang Hyun Park, Pyung Bok Lee, Ghee Young Choe, Jee Yeon Moon, Francis Sahngun Nahm, Yong Chul Kim |
Journal | The Korean journal of pain
(Korean J Pain)
Vol. 27
Issue 3
Pg. 219-28
(Jul 2014)
ISSN: 2005-9159 [Print] Korea (South) |
PMID | 25031807
(Publication Type: Journal Article)
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