Abstract | BACKGROUND: The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the beneficial effect of NML from healthy mice on acute kidney injury (AKI) induced by lipopolysaccharide (LPS) in mice. METHODS: The mice in LPS and LPS + NML groups received an intraperitoneal injection of LPS (35 mg/kg). One hour later, the treatment of NML was performed and kept for 6 h. Then, the renal function indices, renal morphology, the levels of phosphorylation mitogen-activated protein kinases (MAPKs), markers of sensitization to LPS, as well as pro-inflammatory mediators in renal tissue were observed. RESULTS: CONCLUSION: The current results indicate that NML alleviates LPS-induced AKI through its attenuation of sensitization to LPS.
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Authors | Zi-Gang Zhao, Li-Min Zhang, Wen Song, Hui-Bo Du, Hao Cui, Chun-Yu Niu |
Journal | Renal failure
(Ren Fail)
Vol. 36
Issue 8
Pg. 1304-9
(Sep 2014)
ISSN: 1525-6049 [Electronic] England |
PMID | 25020070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acute-Phase Proteins
- Carrier Proteins
- Lipopolysaccharide Receptors
- Lipopolysaccharides
- Membrane Glycoproteins
- lipopolysaccharide-binding protein
- Mitogen-Activated Protein Kinases
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Topics |
- Acute Kidney Injury
(chemically induced, surgery)
- Acute-Phase Proteins
(physiology)
- Animals
- Carrier Proteins
(physiology)
- Lipopolysaccharide Receptors
(physiology)
- Lipopolysaccharides
(administration & dosage)
- Lymph Nodes
(transplantation)
- Membrane Glycoproteins
(physiology)
- Mesentery
- Mice
- Mitogen-Activated Protein Kinases
(physiology)
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