Crosstalk between TGF-β1 and CXCR3 signaling during urethral fibrosis.

Abstract	Urethral fibrosis is an important pathological feature of urethral stricture. TGF-β1 and CXC chemokine receptor 3 (CXCR3) signaling have been reported as the critical pathways involved in the pathology of fibrosis. Here, we collected the urine samples from the patients with recurring urethral stricture, recurring stricture treated by cystostomy, and age- and gender-matched healthy people. ELISA detection revealed that TGF-β1 level was significantly up-regulated for the urethral stricture patients. By contrast, flow cytometry, real-time PCR detection, and immunofluoresecent staining showed that urethral stricture resulted in decreased expression of CXCR3. TGF-β1 treatment could increase cell proliferation and migration ability of urethra fibroblasts, whereas IP-10/CXCR3 signaling showed the opposite effect. Further, we found a crosstalk between TGF-β1 and CXCR3 signaling in the regulation of urethral fibrosis. Thus, pharmacological intervention of TGF-β1 or CXCR3 signaling has a potential as the therapeutic target for the prevention of urethral fibrosis.
Authors	Hong Xie, Chao Feng, Qiang Fu, Ying-Long Sa, Yue-Min Xu
Journal	Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 394 Issue 1-2 Pg. 283-90 (Sep 2014) ISSN: 1573-4919 [Electronic] Netherlands
PMID	24907118 (Publication Type: Journal Article)
Chemical References	CXCR3 protein, human Receptors, CXCR3 Receptors, Transforming Growth Factor beta TGFB1 protein, human Transforming Growth Factor beta1 Protein Serine-Threonine Kinases Receptor, Transforming Growth Factor-beta Type II
Topics	Case-Control Studies Cell Movement Cell Proliferation Cell Survival Cells, Cultured Cystostomy Fibroblasts (metabolism, pathology) Fibrosis Humans Protein Serine-Threonine Kinases (genetics, metabolism) RNA Interference Receptor, Transforming Growth Factor-beta Type II Receptors, CXCR3 (metabolism) Receptors, Transforming Growth Factor beta (genetics, metabolism) Recurrence Signal Transduction Time Factors Transfection Transforming Growth Factor beta1 (metabolism, urine) Urethra (metabolism, pathology, surgery) Urethral Stricture (genetics, metabolism, pathology, surgery, urine)

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