GADD45 proteins: roles in cellular senescence and tumor development.

Abstract

The growth arrest and DNA damage 45 (GADD45) family genes regulate DNA repair, cell cycle, cell survival, apoptosis, senescence, and DNA demethylation in the cells under various stress stimuli, such as oxidative stress, UV radiation, and oncogenic stress. Recent studies have provided important insights regarding how different oncogenic stresses activate GADD45 signaling pathway and lead to disparate influences on tumor initiation. In this review, we discuss the deregulation and cellular function of GADD45 proteins in the context of cancer development. We also highlight recent advances in exploring the tumor suppressive function of GADD45 proteins-triggered cellular senescence.

• Authors: Li Zhang, Zhaojuan Yang, Yongzhong Liu
• Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (Maywood)) Vol. 239 Issue 7 Pg. 773-778 (Jul 2014) ISSN: 1535-3699 [Electronic] England
• PMID: 24872428 (Publication Type: Journal Article)
• Copyright: © 2014 by the Society for Experimental Biology and Medicine.