Abstract |
Animal models of Alzheimer's disease (AD) which emphasize activation of microglia may have particular utility in correlating proinflammatory activity with neurodegeneration. This paper reviews injection of amyloid- β (A β ) into rat brain as an alternative AD animal model to the use of transgenic animals. In particular, intrahippocampal injection of Aβ 1-42 peptide demonstrates prominent microglial mobilization and activation accompanied by a significant loss of granule cell neurons. Furthermore, pharmacological inhibition of inflammatory reactivity is demonstrated by a broad spectrum of drugs with a common endpoint in conferring neuroprotection in peptide-injected animals. Peptide-injection models provide a focus on glial cell responses to direct peptide injection in rat brain and offer advantages in the study of the mechanisms underlying neuroinflammation in AD brain.
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Authors | James G McLarnon |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2014
Pg. 923670
( 2014)
ISSN: 2314-6141 [Electronic] United States |
PMID | 24822221
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Alzheimer Disease
(chemically induced, immunology, physiopathology)
- Amyloid beta-Peptides
(administration & dosage)
- Animals
- Brain
(immunology, physiopathology)
- Brain Chemistry
- Disease Models, Animal
- Rats
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