Abstract | AIM: METHODS: Three non-diabetic, female patients (age 37, 44 and 35 years, respectively) were declared candidates for surgery, between May and September 2011, because of pancreatic body/neck cystic lesions. The planned operation was an LSPDP associated with AIT from the normal pancreas distal to the neoplasm. Islets isolation was performed on the residual pancreatic parenchyma after frozen section examination of the margin. Purified autologous islets were infused into the portal vein by a percutaneous transhepatic approach the day after surgery. RESULTS: The procedure was performed successfully in all the three cases, and the spleen was preserved along with its vessels. Mean operation time was 283 ± 52 min and average blood loss was 133 ± 57 mL. Residual pancreas weights were 33, 22 and 30 g, and 105.200, 40.390 and 94.790 islet equivalents were isolated, respectively. Surgical complications occurred in one patient (grade A pancreatic fistula). Postoperative stays were 6, 6 and 7 d, respectively. Histopathological evaluation revealed mucinous cystic neoplasm in cases 1 and 3, and serous cystic neoplasm in patient 2. No postoperative insulin administration was required. One patient developed a transient partial portal thrombosis 2 mo after islet infusion. Patients are insulin independent at a mean follow up of 8 ± 2 mo. CONCLUSION: Combination of LSPDP and AIT is feasible and could be effective to minimize the surgical impact for benign neoplasm of pancreatic body-neck.
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Authors | Gianpaolo Balzano, Michele Carvello, Lorenzo Piemonti, Rita Nano, Riccardo Ariotti, Alessia Mercalli, Raffaella Melzi, Paola Maffi, Marco Braga, Carlo Staudacher |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 20
Issue 14
Pg. 4030-6
(Apr 14 2014)
ISSN: 2219-2840 [Electronic] United States |
PMID | 24744593
(Publication Type: Case Reports, Journal Article)
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Topics |
- Abdominal Pain
(diagnostic imaging, pathology)
- Adult
- Female
- Humans
- Islets of Langerhans
(pathology)
- Islets of Langerhans Transplantation
- Laparoscopy
(methods)
- Pancreas
(pathology)
- Pancreatectomy
(methods)
- Pancreatic Neoplasms
(surgery, therapy)
- Renal Colic
(diagnostic imaging, pathology)
- Spleen
(surgery)
- Tomography, X-Ray Computed
- Transplantation
- Treatment Outcome
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