Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon.

Abstract

Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.

• Authors: Sergio de Almeida Basano, Gilberto Fontes, Jansen Fernandes Medeiros, Juliana Souza de Almeida Aranha Camargo, Luana Janaína Souza Vera, Marcos Paulo Parente Araújo, Maira Santiago Pires Parente, Ricardo de Godoi Mattos Ferreira, Pedro di Tárique Barreto Crispim, Luís Marcelo Aranha Camargo
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 90 Issue 6 Pg. 1170-5 (Jun 2014) ISSN: 1476-1645 [Electronic] United States
• PMID: 24710613 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The American Society of Tropical Medicine and Hygiene.

Chemical References

• Antiparasitic Agents
• Ivermectin

Topics

• Adolescent
• Adult
• Animals
• Antiparasitic Agents (therapeutic use)
• Brazil
• Child
• Child, Preschool
• Female
• Hematologic Tests
• Humans
• Ivermectin (therapeutic use)
• Male
• Mansonella (drug effects)
• Mansonelliasis (drug therapy)
• Microfilariae
• Middle Aged
• Parasitemia
• Rural Population
• Treatment Outcome
• Young Adult