Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: A response was seen in all patients, with an increase in both immature myeloid cells in the bone marrow and mature granulocytes in the peripheral blood. The dose levels that could stimulate granulocytopoiesis differed among patients. CONCLUSION: These results suggest that, at least in some cases of myelodysplastic syndromes, granulocytopenia can be improved by G-CSF, although it still remains to be determined whether the increase in the number of granulocytes is due to the differentiation and maturation of the myelodysplastic clone or restoration of a residual normal clone.
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Authors | Y Kobayashi, T Okabe, K Ozawa, S Chiba, M Hino, K Miyazono, A Urabe, F Takaku |
Journal | The American journal of medicine
(Am J Med)
Vol. 86
Issue 2
Pg. 178-82
(Feb 1989)
ISSN: 0002-9343 [Print] United States |
PMID | 2464280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Colony-Stimulating Factors
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Anemia, Refractory
(therapy)
- Anemia, Refractory, with Excess of Blasts
(therapy)
- Bone Marrow
(pathology)
- Colony-Stimulating Factors
(administration & dosage, therapeutic use)
- Female
- Granulocyte Colony-Stimulating Factor
- Granulocytes
(pathology)
- Humans
- Leukemia, Myeloid, Acute
(therapy)
- Leukocyte Count
- Male
- Middle Aged
- Myelodysplastic Syndromes
(pathology, therapy)
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