[A case report of extragonadal germ cell tumor with special reference to VAB-6 therapy].

Abstract

A 24-year-old man with a large abdominal mass in addition to the left lymph node swelling was referred to our clinic. Neither testicular nodulus nor overt evidence of tumor development in the scrotal cavity was confirmed by careful palpation and testicular biopsy. Values of lactate dehydrogenase, alpha-fetoprotein, human chorionic gonadotropin (HCG) and beta-HCG in the serum were markedly elevated. The specimen removed from the left cervical lymph node demonstrated mixed type of choriocarcinoma and embryonal carcinoma. A partial response near complete remission was achieved following the VAB-6 combination therapy (cyclophosphamide, vinblastine, actinomycin D, bleomycin, cis-platinum). The patient has been in good health with normal tumor markers and abdominal CT findings.

• Authors: M Iwasaki, T Kazama, T Nakada, T Katayama
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 34 Issue 5 Pg. 883-8 (May 1988) ISSN: 0018-1994 [Print] Japan
• PMID: 2459940 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• Bleomycin
• Chlorambucil
• Dactinomycin
• Vinblastine
• Doxorubicin
• Cyclophosphamide
• Cisplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (blood)
• Bleomycin (administration & dosage)
• Chlorambucil (administration & dosage)
• Choriocarcinoma (blood, drug therapy, pathology)
• Cisplatin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Dactinomycin (administration & dosage)
• Doxorubicin (administration & dosage)
• Humans
• Lymphatic Metastasis
• Male
• Neck
• Neoplasms, Multiple Primary (blood, drug therapy, pathology)
• Remission Induction
• Retroperitoneal Neoplasms (blood, drug therapy, pathology)
• Teratoma (blood, drug therapy, pathology)
• Vinblastine (administration & dosage)