[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].

Abstract

The activity of liver and Guerin's carcinoma microsomal NADH-dependent reductase system has been investigated in tumor-bearing rats exposed to preliminary irradiation. Preliminary irradiation of rats (before transplantation of Guerin's carcinoma) resulted in the decrease of NADH-cytochrome b5 reductase activity and contents of cytochrome b5 in the Guerin's carcinoma microsomal fraction in the logarithmic phases of oncogenesis compared with the non-irradiated tumor-bearing rats. The effect of irradiation preceding transplantation of the tumor to rats results in the increase of enzymatic activities of liver microsomal NADH-cytochrome b5 reductase in the latent and logarithmic phases of tumor growth as compared with non-irradiated tumor-bearing rats. At the same time the contents of cytochrome b5 decreases. During longer periods after irradiation the investigated parameters approached to those in the group of non-irradiated tumor-bearing animals.

• Authors: M M Marchenko, O V Ketsa
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2013 Nov-Dec Vol. 59 Issue 6 Pg. 662-72 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 24511678 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytochromes b5
• Cytochrome-B(5) Reductase

Topics

• Animals
• Cytochrome-B(5) Reductase (metabolism)
• Cytochromes b5 (metabolism)
• Female
• Lipid Peroxidation (radiation effects)
• Liver (enzymology, radiation effects)
• Microsomes, Liver (enzymology, metabolism, radiation effects)
• Neoplasm Transplantation
• Neoplasms, Experimental (enzymology, metabolism)
• Oxidation-Reduction
• Radiation Dosage
• Rats