Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing.

Abstract

In this study, an antibacterial electrospun nanofibrous scaffolds with diameters around 400-700 nm were prepared by physically blending polyurethane (PU) with two biopolymers such as cellulose acetate (CA) and zein. Here, PU was used as the foundation polymer, was blended with CA and zein to achieve desirable properties such as better hydrophilicity, excellent cell attachment, proliferation and blood clotting ability. To prevent common clinical infections, an antimicrobial agent, streptomycin sulfate was incorporated into the electrospun fibers and its antimicrobial ability against the gram negative and gram positive bacteria were examined. The interaction between fibroblasts and the PU-CA and PU-CA-zein-drug scaffolds such as viability, proliferation, and attachment were characterized. PU-CA-zein-drug composite nanoscaffold showed enhanced blood clotting ability in comparison with pristine PU nanofibers. The presence of CA and zein in the nanofiber membrane improved its hydrophilicity, bioactivity and created a moist environment for the wound, which can accelerate wound recovery.

• Authors: Afeesh Rajan Unnithan, Gopalsamy Gnanasekaran, Yesupatham Sathishkumar, Yang Soo Lee, Cheol Sang Kim
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 102 Pg. 884-92 (Feb 15 2014) ISSN: 1879-1344 [Electronic] England
• PMID: 24507360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Polyurethanes
• acetylcellulose
• Cellulose
• Zein

Topics

• 3T3-L1 Cells
• Animals
• Anti-Bacterial Agents (administration & dosage, pharmacology, therapeutic use)
• Bandages
• Blood Coagulation (drug effects)
• Cellulose (administration & dosage, analogs & derivatives)
• Humans
• Mice
• Microbial Sensitivity Tests
• Microscopy, Electron, Scanning
• Platelet Activation (drug effects)
• Polyurethanes (administration & dosage)
• Wounds and Injuries (therapy)
• Zein (administration & dosage)